What Does ceesdekker.net Mean?
What Does ceesdekker.net Mean?
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Rotary motion of DNA rotors on nanopores. Top rated row: raw online video on the Cy5 channel of every rotor. Center row: corresponding solitary-particle localization results of both equally ends of your DNA rotors. The placement of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames before The present body is proven as good traces.
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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters
We produce level-of-care diagnostics exam of neglected tropical disorders in resource-confined configurations, determined by Crspr/Cas9 detecting of pathogen’s DNA in human body fluids.
SMC complexes can go Actual physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which assess the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives include things like the next:
Instance (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim in the pore is highlighted in purple, in addition to a 3D rendering from the motion on the DNA rod is exhibited.
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Pretty great, but that wasn’t definitely exactly where my fascination lay. I needed to pioneer and I had the sensation which was now not achievable, as the most interesting basic insights experienced now been uncovered. But my area had formulated lots of thrilling new equipment to evaluate unique molecules. I decided that I desired to use this to biology, to take a look at it from the Actual physical standpoint.’
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2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; learned a big velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of sound in carbon nanotubes in liquid
2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes